Drug stability expiration dating
It is important to keep in mind that the expiry date of a drug is based on testing of previously unopened products, stored in its original container, and maintained under typical conditions.Once you open a bottle, or transfer it to another container (like a prescription vial), the manufacturer’s expiry date is no longer reliable.Epinephrine for injection is unstable, and you’re lucky to find a product that expires more than 18 months after you get it.(The Pro Publica article points out that this may, in fact, be overstated.) Other drug products are highly sensitive to moisture, requiring dispensing in specialized containers with dessicants to trap moisture and enhance stability.Again, the evidence is reassuring – with some caveats.The best way to verify long-term stability would be to stockpile supplies, let them sit for years, and even decades, and then test them.The final dosage form may be a mix of the API as well as fillers, binders, and other ingredients to ensure the API is delivered to the body in a reliable and predictable manner.But what certainty do we have that this new dosage form will maintain all of these properties over time?
If expiry dates are nonsense, extending them could have considerable economic and environmental benefits. They’re based on the chemical characteristics of the product itself.
https:// " data-medium-file="https://sciencebasedmedicine.org/wp-content/uploads/2017/07/5473319462_fb6dcea35d_z.jpg" data-large-file="https://sciencebasedmedicine.org/wp-content/uploads/2017/07/5473319462_fb6dcea35d_z.jpg" class="aligncenter size-full wp-image-48844" src=" alt="Expired medicines" width="640" height="480" / Imagine that’s the contents of your medicine cabinet above. Others believe that drugs start deteriorating long before the expiry date. Expiry dates are the source of a lot of questions to pharmacists.
Some feel the expiry date is purely a plot of Big Pharma to sell more drugs.
Many liquid antibiotics have very poor stability, so they must be prepared in the pharmacy at the time of dispensing.
Refrigeration is necessary for other drugs, ranging from vaccines to eyedrops, which keeps the dosage form stable.